- Trumpet satinash (Syzygium claviflorum) is a member of the Myrtaceae family, which includes 4,500-5,000 species of evergreen trees or shrubs that are found in the Mediterranean region, sub-Saharan Africa, Madagascar, tropical and temperate Asia, Australia, the Pacific Islands, and tropical South America. Betulinic acid is the main constituent of trumpet satinash and is believed to be responsible for its effects.
- Betulinic acid may have antitumor activity. Betulinic acid derivatives may have antiretroviral activity. However, there is currently a lack of clinical evidence in support of the use of trumpet satinash for any condition.
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Trumpetsatinash
Contents
- Dang Z, Lai W, Qian K, et al. Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors. J Med Chem 2009;52(23):7887-7891. View Abstract
- Drag M, Surowiak P, Drag-Zalesinska M, et al. Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines. Molecules 2009;14(4):1639-1651. View Abstract
- Drag-Zalesinska M, Kulbacka J, Saczko J, et al. Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. Bioorg Med Chem Lett 2009;19(16):4814-4817. View Abstract
- Eksioglu-Demiralp E, Kardas ER, Ozgul S, et al. Betulinic acid protects against ischemia/reperfusion-induced renal damage and inhibits leukocyte apoptosis. Phytother Res 2010;24(3):325-332. View Abstract
- Fulda S. Betulinic acid: a natural product with anticancer activity. Mol Nutr Food Res 2009;53(1):140-146. View Abstract
- Fulda S. Betulinic Acid for cancer treatment and prevention. Int J Mol.Sci 2008;9(6):1096-1107. View Abstract
- Fulda S, Kroemer G. Targeting mitochondrial apoptosis by betulinic acid in human cancers. Drug Discov Today 2009;14(17-18):885-890. View Abstract
- Goff RD, Thorson JS. Enhancing the divergent activities of betulinic acid via neoglycosylation. Org Lett 2009;11(2):461-464. View Abstract
- Karna E, Palka JA. Mechanism of betulinic acid inhibition of collagen biosynthesis in human endometrial adenocarcinoma cells. Neoplasma 2009;56(4):361-366. View Abstract
- Mullauer FB, Kessler JH, Medema JP. Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion. Apoptosis 2009;14(2):191-202. View Abstract
- Nakagawa-Goto K, Yamada K, Taniguchi M, et al. Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents. Bioorg Med Chem Lett 2009;19(13):3378-3381. View Abstract
- Qian K, Yu D, Chen CH, et al. Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents. J Med Chem 2009;52(10):3248-3258. View Abstract
- Theo A, Masebe T, Suzuki, Y, et al. Peltophorum africanum, a traditional South African medicinal plant, contains an anti HIV-1 constituent, betulinic acid. Tohoku J Exp Med 2009;217(2):93-99. View Abstract
- Willmann M, Wacheck V, Buckley J, et al. Characterization of NVX-207, a novel betulinic acid-derived anti-cancer compound. Eur J Clin Invest 2009;39(5):384-394. View Abstract
- Yao D, Li H, Gou Y, et al. Betulinic acid-mediated inhibitory effect on hepatitis B virus by suppression of manganese superoxide dismutase expression. FEBS J 2009;276(9):2599-2614. View Abstract
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