- Phosphatidylserine is present in cell membranes and is the major molecule of its kind in the brain. Phosphatidylserine is essential for cell-to-cell communication and other cell functions.
- Phosphatidylserine is present in greater amounts in animal-based foods, such as liver and kidneys, than in plants. Plant sources include soy beans, white beans, cabbage, carrots, whole-grain barley, and rice.
- Phosphatidylserine is most commonly used for the treatment of central nervous system (CNS) disorders. It is commonly used to treat mental disorders ranging from age-associated memory impairment (AAMI) to Alzheimer's disease. Current evidence suggests that phosphatidylserine may benefit those with AAMI to a greater degree than it does those with Alzheimer's disease. However, more research is needed.
- Ingestion of phosphatidylserine from bovine brain cortex (BC-PS) carries a risk of transmission of infectious disease, such as bovine spongiform encephalopathy (commonly known as mad cow disease). However, phosphatidylserine derived from soybeans (S-PS) does not carry that risk, and it appears to be equally effective as BC-PS.
- Soy-derived phosphatidylserine (S-PS) is listed on the U.S. Food and Drug Administration (FDA) Generally Recognized as Safe (GRAS) list.
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Phosphatidylserine
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- Ayub K, Hallett MB. Signalling shutdown strategies in aging immune cells. Aging Cell 2004;3(4):145-149. View Abstract
- Beaumont C, Canonne-Hergaux F. [Erythrophagocytosis and recycling of heme iron in normal and pathological conditions; regulation by hepcidin]. Transfus Clin Biol 2005;12(2):123-130. View Abstract
- Bessos H, Seghatchian J. Red cell storage lesion: the potential impact of storage-induced CD47 decline on immunomodulation and the survival of leucofiltered red cells. Transfus Apher Sci. 2005;32(2):227-232. View Abstract
- Ceccatelli S, Tamm C, Sleeper E, et al. Neural stem cells and cell death. Toxicol Lett 2004;149(1-3):59-66. View Abstract
- Crook T, Petrie W, Wells C, et al. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28(1):61-66. View Abstract
- Emmelot P, Van Hoeven RP. Phospholipid unsaturation and plasma membrane organization. Chem Phys Lipids 1975;14(3):236-246. View Abstract
- Folch J. The chemical structure of phospatidyl serine. J Biol Chem 1948;174(2):439-450. View Abstract
- Haberkorn U, Altmann A, Mier W, et al. Molecular imaging of tumor metabolism and apoptosis. Ernst Schering Found Symp Proc 2007;(4):125-152. View Abstract
- Hallgren O, Aits S, Brest P, et al. Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells). Adv Exp Med Biol 2008;606:217-240. View Abstract
- Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
- Maggioni, M., Picotti, G. B., Bondiolotti, G. P., et al. Effects of phosphatidylserine therapy in geriatric patients with depressive disorders. Acta Psychiatr.Scand. 1990;81(3):265-270. View Abstract
- Mountz JD, Hsu HC, Wu Q, et al. Molecular imaging: new applications for biochemistry. J Cell Biochem Suppl 2002;39:162-171. View Abstract
- Nerozzi, D., Aceti, F., Melia, E., et al. [Phosphatidylserine and memory disorders in the aged]. Clin.Ter. 3-15-1987;120(5):399-404. View Abstract
- Ransmayr, G., Plorer, S., Gerstenbrand, F., et al. Double-blind placebocontrolled trial of phosphatidylserine in elderly patients with arteriosclerotic encephalopathy. Clin Trials J 1987;24:62-72.
- Rosadini, G., Sannita, W. G., Nobili, F., et al. Phosphatidylserine: quantitative EEG effects in healthy volunteers. Neuropsychobiology 1990;24(1):42-48. View Abstract
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