- Perillyl alcohol is isolated from the essential oils of several plants including cherries, lavender, peppermint, spearmint, celery seeds, sage, cranberries, lemongrass, ginger grass, savin juniper, Conyza newii, caraway, Perilla frutescens, and wild bergamont.
- Animal studies suggest that perillyl alcohol may help slow growth of pancreatic, mammary, and liver tumors. It may also help colon, lung, and skin cancer. Perillyl alcohol is under sponsorship from the National Cancer Institute (NCI), and is undergoing phase II clinical trials.
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ingredients
Perillyl alcohol
Contents
- Azzoli CG, Miller VA, Ng KK, et al. A phase I trial of perillyl alcohol in patients with advanced solid tumors. Cancer Chemother.Pharmacol. 2003;51(6):493-498.
View Abstract - Bailey HH, Wilding G, Tutsch KD, et al. A phase I trial of perillyl alcohol administered four times daily for 14 days out of 28 days. Cancer Chemother.Pharmacol. 2004;54(4):368-376.
View Abstract - Berchtold CM, Chen KS, Miyamoto S, Gould MN. Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway. Cancer Res 9-15-2005;65(18):8558-8566.
View Abstract - Chan NL, Wang H, Wang Y, et al. Polycyclic aromatic hydrocarbon-induced CYP1B1 activity is suppressed by perillyl alcohol in MCF-7 cells. Toxicol.Appl.Pharmacol. 11-21-2005.
View Abstract - Chen Y, Hu D. Effects of POH in combination with STI571 on the proliferation and apoptosis of K562 cells. J Huazhong.Univ Sci Technolog.Med Sci 2004;24(1):41-44.
View Abstract - Chung BH, Lee HY, Lee JS, Young CY. Perillyl alcohol inhibits the expression and function of the androgen receptor in human prostate cancer cells. Cancer Lett. 7-16-2005.
View Abstract - Clark SS. Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells. Oncology 2006;70(1):13-18.
View Abstract - da Fonseca CO, Landeiro JA, Clark SS, et al. Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol. Surg Neurol 2006;65 Suppl 1:S1.
View Abstract - Fernandes J, da Fonseca CO, Teixeira A, Gattass CR. Perillyl alcohol induces apoptosis in human glioblastoma multiforme cells. Oncol.Rep. 2005;13(5):943-947.
View Abstract - Morgan-Meadows S, Dubey S, Gould M, et al. Phase I trial of perillyl alcohol administered four times daily continuously. Cancer Chemother.Pharmacol. 2003;52(5):361-366.
View Abstract - Omolo MO, Okinyo D, Ndiege IO, et al. Fumigant toxicity of the essential oils of some African plants against Anopheles gambiae sensu stricto. Phytomedicine. 2005;12(3):241-246.
View Abstract - Samaila D, Toy BJ, Wang RC, Elegbede JA. Monoterpenes enhanced the sensitivity of head and neck cancer cells to radiation treatment in vitro. Anticancer Res 2004;24(5A):3089-3095.
View Abstract - Stearns V, Coop A, Singh B, et al. A pilot surrogate end point biomarker trial of perillyl alcohol in breast neoplasia. Clin Cancer Res 11-15-2004;10(22):7583-7591.
View Abstract - Xu M, Floyd HS, Greth SM, et al. Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects. Toxicol.Appl.Pharmacol. 3-1-2004;195(2):232-246.
View Abstract - Yuri T, Danbara N, Tsujita-Kyutoku M, et al. Perillyl alcohol inhibits human breast cancer cell growth in vitro and in vivo. Breast Cancer Res Treat. 2004;84(3):251-260.
View Abstract
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