← Back to Monographs
Manganese

Manganese

ingredients

Contents

  • Manganese is an essential trace nutrient. The human body contains about 10 milligrams of manganese, which is stored mainly in the liver, kidneys, pancreas, and bones.In the human brain, manganese is bound to manganese metalloproteins. Manganese activates enzymes responsible for the use of several key nutrients, including B vitamins (biotin, thiamin), vitamin C, and choline. It aids in the synthesis of fatty acids and cholesterol, facilitates protein and carbohydrate metabolism, and may also participate in the production of sex hormones and maintaining reproductive health.
  • Manganese has been examined as a treatment for a variety of conditions, including osteoarthritis and wound healing. However, manganese is often used in combination with other vitamins and/or minerals. Therefore, the effects of manganese alone are difficult to determine.
  • Chronic exposure to excessive manganese levels can lead to a variety of psychiatric and motor disturbances, termed manganism.
  • Benevolenskaia LI, Toroptsova NV, Nikitinskaia OA, et al. [Vitrum osteomag in prevention of osteoporosis in postmenopausal women: results of the comparative open multicenter trial]. Ter Arkh. 2004;76(11):88-93.
    View Abstract
  • Czeizel AE, Dudás I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med. 1992 Dec 24;327(26):1832-5.
    View Abstract
  • Das A Jr, Hammad TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. 2000 Sep;8(5):343-50.
    View Abstract
  • Davison GW, Hughes CM, Bell RA. Exercise and mononuclear cell DNA damage: the effects of antioxidant supplementation. Int J Sport Nutr Exerc Metab. 2005 Oct;15(5):480-92.
    View Abstract
  • El-Attar M, Said M, El-Assal G, et al. Serum trace element levels in COPD patient: the relation between trace element supplementation and period of mechanical ventilation in a randomized controlled trial. Respirology. 2009 Nov;14(8):1180-7. Epub 2009 Sep 16.
    View Abstract
  • Harrison RL, Cheraskin E, Ringsdorf WM Jr, et al. The effect of multivitamin-trace mineral versus placebo supplementation upon the height-weight ratio (ponderal index). Int Z Vitaminforsch. 1969;39(4):486-91.
    View Abstract
  • Koch G. Comparison and estimation of effect on caries of daily supervised toothbrushing with a dentifrice containing sodium fluoride and a dentifrice containing potassium fluoride and manganese chloride. A three-year clinical test. Odontol Revy. 1972;23(3):341-54.
    View Abstract
  • Leffler CT, Philippi AF, Leffler SG, et al. Glucosamine,chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study. Mil Med. 1999 Feb;164(2):85-91.
    View Abstract
  • Penland JG, Johnson PE. Dietary calcium and manganese effects on menstrual cycle symptoms. Am J Obstet Gynecol. 1993 May;168(5):1417-23.
    View Abstract
  • Rivera JA, González-Cossío T, Flores M, et al. Multiple micronutrient supplementation increases the growth of Mexican infants. Am J Clin Nutr. 2001 Nov;74(5):657-63.
    View Abstract
  • Salducci J, Planche D. [A therapeutic trial in patients with spasmophilia]. Sem Hop. 1982 Oct 7;58(36):2097-100.
    View Abstract
  • Stewart S, Prince M, Bassendine M, et al. A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis. J Hepatol. 2007 Aug;47(2):277-83.
    View Abstract
  • Strause L, Saltman P, Smith KT, et al. Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. J Nutr. 1994 Jul;124(7):1060-4.
    View Abstract
  • Uusitalo L, Kenward MG, Virtanen SM, et al. Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced beta cell autoimmunity in the child. Am J Clin Nutr. 2008 Aug;88(2):458-64.
    View Abstract
  • Whelan AM, Jurgens TM, Bowles SK. Natural health products in the prevention and treatment of osteoporosis: systematic review of randomized controlled trials. Ann Pharmacother. 2006 May;40(5):836-49.
    View Abstract