- Boneset (Eupatorium perfoliatum) is native to eastern North America and was used by Native Americans to treat fevers, including dengue fever and malaria. Today, boneset is used primarily in homeopathic medicine for fevers, influenza (flu), digestive problems, and liver disorders. However, the use of boneset is limited because other drugs generally are more effective.
- Boneset may be effective when taken by mouth as an immunostimulant and an anti-inflammatory agent. However, there is insufficient reliable information available about the effectiveness of boneset for its other uses.
- Products containing boneset have been placed in the "Herbs of Undefined Safety" category by the U.S. Food and Drug Administration (FDA).
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Boneset (Eupatorium perfoliatum)
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Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to . Selected references are listed below.
- Gassinger CA, Wunstel G, Netter P. [A controlled clinical trial for testing the efficacy of the homeopathic drug eupatorium perfoliatum D2 inthe treatment of common cold (author's transl)]. Arzneimittelforschung 1981;31(4):732-736.
View Abstract - Habtemariam S, Macpherson AM. Cytotoxicity and antibacterial activity of ethanol extract from leaves of a herbal drug, boneset (Eupatorium perfoliatum). Phytother Res 2000;14(7):575-577.
View Abstract - Herz W, Kalyanaraman PS, Ramakrishnan G. Sesquiterpene lactones of Eupatorium perfoliatum. J Org Chem 6-24-1977;42(13):2264-2271.
View Abstract - Wagner H, Jurcic, K. [Immunologic studies of plant combination preparations. In-vitro and in-vivo studies on the stimulation of phagocytosis]. Arzneimittelforschung 1991;41(10):1072-1076.
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