- Boldo is an evergreen shrub found in the Andean regions of Chile and Peru, and also is native to parts of Morocco. Boldo was employed in Chilean and Peruvian folk medicine and recognized as an herbal remedy in a number of pharmacopoeias, mainly for the treatment of liver ailments.
- Boldine, a major alkaloidal constituent found in the leaves and bark of the boldo tree, has been shown to possess antioxidant and anti-inflammatory activity. The German Commission E has approved boldo leaf as treatment for mild dyspepsia (upset stomach) and spastic gastrointestinal complaints. Well-designed human studies on the efficacy of boldo are lacking.
← Back to Monographs
ingredients
Boldo (Peumus boldus)
Contents
- Almeida ER, Melo AM, Xavier H. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytother Res 2000;14(2):99-102.
View Abstract - Jang YY, Song JH, Shin YK, et al. Protective effect of boldine on oxidative mitochondrial damage in streptozotocin-induced diabetic rats. Pharmacol Res 2000;42(4):361-371.
View Abstract - Jimenez I, Garrido A, Bannach R, et al. Protective effects of boldine against free radical-induced erythrocyte lysis. Phytother Res 2000;14(5):339-343.
View Abstract - Kang JJ, Cheng YW. Effects of boldine on mouse diaphragm and sarcoplasmic reticulum vesicles isolated from skeletal muscle. Planta Med 1998;64(1):18-21.
View Abstract - Kang JJ, Cheng YW, Fu WM. Studies on neuromuscular blockade by boldine in the mouse phrenic nerve-diaphragm. Jpn J Pharmacol 1998;76(2):207-212.
View Abstract - Kubinova R, Machala M, Minksova K, et al. Chemoprotective activity of boldine: modulation of drug-metabolizing enzymes. Pharmazie 2001;56(3):242-243.
View Abstract - Lambert JP, Cormier A. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21(4):509-512.
View Abstract - Monzon S, Lezaun A, Saenz D, et al. Anaphylaxis to boldo infusion, a herbal remedy. Allergy 2004;59(9):1019-1020.
View Abstract - Piscaglia F, Leoni S, Venturi A, et al. Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity. Scand J Gastroenterol 2005;40(2):236-239.
View Abstract - Rancan F, Rosan S, Boehm K, et al. Protection against UVB irradiation by natural filters extracted from lichens. J Photochem Photobiol B 2002;68(2-3):133-139.
View Abstract - Reiniger IW, de Oliveira JF, Caldeira-de-Araujo A, et al. Effect of Peumus boldus on the labeling of red blood cells and plasma proteins with technetium-99m. Appl Radiat Isot 1999;51(2):145-149.
View Abstract - Schmeda-Hirschmann G, Rodriguez JA, Theoduloz C, et al. Free-radical scavengers and antioxidants from Peumus boldus Mol. ("Boldo"). Free Radic Res 2003;37(4):447-452.
View Abstract - Silva E, Jopia M, Edwards AM, et al. Protective effect of Boldo and tea infusions on the visible light-mediated pro-oxidant effects of vitamin B2, riboflavin. Photochem Photobiol 2002;75(6):585-590.
View Abstract - Speisky H, Rocco C, Carrasco C, et al. Antioxidant screening of medicinal herbal teas. Phytother Res 2006;20(6):462-467.
View Abstract - Teng CM, Hsueh CM, Chang YL, et al. Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. J Pharm Pharmacol 1997;49(7):706-711.
View Abstract
Disclaimer: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.
